Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | USP14 | P54578 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19501173 | 0.81 | SMN1; SMN2 (0.53) | NOTUMALDH1A1HPGDSMN1; SMN2USP14 | |
| SCHEMBL6921452 | 0.79 | USP14 (0.56) | NOTUMIGF1RALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL21165029 | 0.76 | HPGD (0.45) | IGF1RALDH1A1MAPTGAAHPGD | |
| SCHEMBL6922487 | 0.75 | SMN1; SMN2 (0.78) | NOTUMALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL19749177 | 0.72 | GAA (0.46) | NOTUMIGF1RALDH1A1MAPTGAA | |
| SCHEMBL21165185 | 0.71 | KDM4E (0.40) | HPGDSMN1; SMN2USP14USP7HTR7 | |
| SCHEMBL23559540 | 0.69 | SMN1; SMN2 (0.49) | NOTUMIGF1RALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL23559501 | 0.68 | SMN1; SMN2 (0.48) | NOTUMIGF1RALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5736618 | 0.67 | L3MBTL1 (0.49) | GAASMN1; SMN2MEN1KMT2AALOX15 | |
| SCHEMBL8944148 | 0.66 | IGF1R (0.79) | IGF1RMAPTRECQLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | NOTUM 2331/4885IGF1R 4166/4885ALDH1A1 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.