Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 15/20 | 0.47 |
| ▸ | NPC1 | O15118 | 15/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.47 |
| ▸ | RAB9A | P51151 | 12/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.45 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116634 | 0.85 | NPC1 (0.34) | MEN1NPC1KMT2ARAB9ACASP3 | |
| SCHEMBL2116501 | 0.78 | MEN1 (0.54) | MEN1NPC1KMT2ARAB9ACASP3 | |
| SCHEMBL2116503 | 0.78 | MEN1 (0.54) | MEN1NPC1KMT2ARAB9ACASP3 | |
| SCHEMBL2118470 | 0.77 | FDPS (0.35) | MEN1NPC1KMT2ARAB9ACASP3 | |
| SCHEMBL2117450 | 0.75 | KMT2A (0.37) | MEN1NPC1KMT2ARAB9AKDM4E | |
| SCHEMBL2117083 | 0.74 | DHODH (0.34) | MEN1KMT2AKDM4EMAPTHTT | |
| SCHEMBL6254433 | 0.68 | ABL1 (0.41) | MEN1NPC1KMT2ARAB9AKDM4E | |
| SCHEMBL8922938 | 0.67 | CYP19A1 (0.36) | MEN1NPC1KMT2ARAB9AKDM4E | |
| SCHEMBL16107255 | 0.67 | KMT2A (0.61) | MEN1NPC1KMT2ARAB9AAGTR1 | |
| SCHEMBL12281289 | 0.66 | CD74 (0.72) | MEN1NPC1KMT2ARAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2012-04-19 | — | — | US | disclosed |
| EP-2250152-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | Novartis AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106586-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094958-A1 | QUINOLINES AS INHIBITORS OF FARNESYL PYROPHOSPHATE SYNTHASE | FDPS, GGPS1, CTPS1 | MEN1 491/4885NPC1 236/4885KMT2A 3963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.