Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MITF | O75030 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | USP14 | P54578 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | USP7 | Q93009 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19749190 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL19501341 | 0.90 | NOTUM (0.58) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL6923175 | 0.87 | SMN1; SMN2 (0.64) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL6922806 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL17949835 | 0.87 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL17949730 | 0.85 | ALDH1A1 (0.67) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL19749202 | 0.84 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL19749200 | 0.80 | USP14 (0.49) | SMN1; SMN2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL17949747 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 | |
| SCHEMBL6922796 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MITFMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351568-B2 | Compositions and methods for enhancing proteasome activity | PSMG3, PSME3, PSMB11 | SMN1; SMN2 307/4885ALDH1A1 4165/4885MITF 2257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.