Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.30 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419964 | 0.99 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21165975 | 0.91 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21166088 | 0.82 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL23100381 | 0.76 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21166089 | 0.75 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL21165813 | 0.74 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL20106620 | 0.74 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL19184807 | 0.73 | GNAI3 (0.39) | MAPTKDM4EALOX15MEN1KMT2A | |
| SCHEMBL24814981 | 0.70 | KCNQ3 (0.33) | CA1CA2MAPTMEN1KMT2A | |
| SCHEMBL19184997 | 0.70 | EPHX2 (0.37) | MAPTKDM4EALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | CHRNB2 504/4885CHRNA4 365/4885CHRNB4 542/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | CHRNB2 504/4885CHRNA4 365/4885CHRNB4 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.