Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | CTSG | P08311 | 1/20 | 0.31 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20106620 | 0.79 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21166014 | 0.76 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21165975 | 0.76 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL15298467 | 0.75 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR | |
| SCHEMBL22419964 | 0.75 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL19504457 | 0.73 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3CA1 | |
| SCHEMBL21191576 | 0.71 | GLB1 (0.32) | SIGMAR1 | |
| SCHEMBL20053357 | 0.69 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3LMNA | |
| SCHEMBL20053294 | 0.69 | GAA (0.46) | TSHRNR1H2POLBSMN1; SMN2TDP1 | |
| SCHEMBL12909937 | 0.68 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210078991-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2021-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078991-A1 | THERAPEUTIC COMPOUNDS | NQO1, HAVCR2, CCR5 | CHRNB2 4524/4885CHRNA4 4694/4885CHRNB4 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.