Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.39 |
| ▸ | CDK2 | P24941 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591031 | 0.90 | MET (0.61) | METMAPK1CCNE1CDK2PDE3B | |
| SCHEMBL22475696 | 0.76 | MET (0.44) | METCCNE1CDK2GPR84JAK2 | |
| SCHEMBL21167329 | 0.75 | MET (0.67) | METMAPK1CCNE1CDK2PDE3B | |
| SCHEMBL21167443 | 0.75 | MET (0.42) | METMAPK1PDE3BPDE3ACYP2C9 | |
| SCHEMBL21167683 | 0.75 | MET (0.47) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12693351 | 0.75 | MET (1.00) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591029 | 0.75 | MET (0.63) | METMAPK1CCNE1CDK2PDE3B | |
| SCHEMBL21167463 | 0.74 | MET (0.43) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL12487758 | 0.74 | MET (0.56) | METMAPK1CCNE1CDK2PDE3B | |
| SCHEMBL24591034 | 0.74 | PIM1 (0.43) | MAPK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |