Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 6/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167685 | 0.88 | MET (0.48) | METJAK2KDR | |
| SCHEMBL16882499 | 0.83 | MET (0.64) | METLRRK2PIM1PIM3PIM2 | |
| SCHEMBL23128008 | 0.81 | MET (0.46) | METLRRK2PIM1PIM3PIM2 | |
| SCHEMBL17425926 | 0.79 | MET (0.49) | METLRRK2PIM1PIM3PIM2 | |
| SCHEMBL12487546 | 0.78 | MET (0.73) | MET | |
| SCHEMBL17425942 | 0.77 | MET (0.43) | METPIM1JAK2DYRK1A | |
| SCHEMBL21167393 | 0.74 | MET (0.44) | METPIM1PIM3PIM2JAK2 | |
| SCHEMBL24591003 | 0.72 | MET (0.42) | METJAK2RETKDRGSK3A | |
| SCHEMBL17425918 | 0.71 | MET (0.59) | METLRRK2PIM1PIM3PIM2 | |
| SCHEMBL24591016 | 0.71 | MET (0.47) | METJAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |