Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24591003 | 0.87 | MET (0.42) | METTYRO3HDAC1HDAC8HDAC6 | |
| SCHEMBL21167681 | 0.86 | CSF1R (0.43) | METCSF1RTYRO3FGFR1FGFR3 | |
| SCHEMBL24591001 | 0.84 | CSF1R (0.58) | METCSF1RFGFR1FGFR2FGFR3 | |
| SCHEMBL24590999 | 0.83 | MET (0.44) | METCSF1RTYRO3PIK3CDPIK3CG | |
| SCHEMBL24590986 | 0.83 | MET (0.59) | METCSF1RTYRO3PIK3CDPIK3CG | |
| SCHEMBL21167754 | 0.78 | MET (0.60) | METCSF1RTYRO3PIK3CDPIK3CG | |
| SCHEMBL17425926 | 0.77 | MET (0.49) | METTYRO3PIM1PIM3PIM2 | |
| SCHEMBL21167368 | 0.76 | MET (0.39) | METCSF1RTYRO3PIK3CDMTOR | |
| SCHEMBL12487546 | 0.74 | MET (0.73) | MET | |
| SCHEMBL21167677 | 0.74 | MET (0.55) | METCSF1RFGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |