Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 5/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475943 | 0.90 | MET (0.59) | METCSF1RTYRO3PIM1PIM3 | |
| SCHEMBL24591013 | 0.87 | MET (0.57) | METCSF1RTYRO3PIM1PIM3 | |
| SCHEMBL21167564 | 0.86 | MET (0.59) | METCSF1RLDHALDHBTYRO3 | |
| SCHEMBL24591021 | 0.85 | MET (0.44) | METCSF1RLDHALDHBPIK3CD | |
| SCHEMBL21167473 | 0.84 | MET (0.47) | METCSF1RLDHALDHBTYRO3 | |
| SCHEMBL21167565 | 0.84 | CSF1R (0.62) | METCSF1RLDHALDHB | |
| SCHEMBL24590999 | 0.84 | MET (0.44) | METCSF1RLDHALDHBTYRO3 | |
| SCHEMBL21167667 | 0.82 | LDHA (0.44) | METCSF1RLDHALDHBATR | |
| SCHEMBL24590986 | 0.80 | MET (0.59) | METCSF1RLDHALDHBTYRO3 | |
| SCHEMBL21167751 | 0.78 | LDHA (0.43) | METCSF1RLDHALDHBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |