Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 9/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167408 | 0.90 | MKNK1 (0.53) | MKNK1ALKNAMPTPAK1MET | |
| SCHEMBL21167583 | 0.83 | MET (0.49) | MKNK1NAMPTPAK1METKEAP1 | |
| SCHEMBL22475713 | 0.79 | MET (0.53) | MKNK1NAMPTPAK1METKEAP1 | |
| SCHEMBL22475857 | 0.79 | MET (0.38) | MKNK1NAMPTPAK1METJAK2 | |
| SCHEMBL23128064 | 0.79 | MET (0.44) | MKNK1NAMPTPAK1METKEAP1 | |
| SCHEMBL22475870 | 0.78 | MET (0.53) | MKNK1NAMPTPAK1METLRRK2 | |
| SCHEMBL21167349 | 0.77 | NTRK1 (0.49) | METNTRK1 | |
| SCHEMBL21167523 | 0.75 | CSF1R (0.42) | MKNK1NAMPTPAK1METKEAP1 | |
| SCHEMBL12489730 | 0.74 | MET (0.54) | MKNK1ALKMET | |
| SCHEMBL22475697 | 0.72 | MET (0.51) | MKNK1PAK1METKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |