Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23128064 | 0.89 | MET (0.44) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL22475697 | 0.88 | MET (0.51) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL22475857 | 0.88 | MET (0.38) | METMKNK1NQO2KEAP1PAK1 | |
| SCHEMBL22475713 | 0.88 | MET (0.53) | METMKNK1KEAP1PAK1NAMPT | |
| SCHEMBL21167340 | 0.87 | MET (0.55) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL22475870 | 0.84 | MET (0.53) | METMKNK1CSF1RKEAP1PAK1 | |
| SCHEMBL21167421 | 0.84 | CSF1R (0.59) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL21167410 | 0.83 | MKNK1 (0.51) | METMKNK1KEAP1PAK1NAMPT | |
| SCHEMBL24591117 | 0.80 | MET (0.53) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL24591043 | 0.77 | MET (0.54) | METMKNK1KEAP1PAK1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |