Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 9/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167583 | 0.88 | MET (0.49) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL22475716 | 0.88 | MET (0.41) | METMKNK1KEAP1PAK1DYRK1A | |
| SCHEMBL21167421 | 0.88 | CSF1R (0.59) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL21167396 | 0.87 | MET (0.39) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL24591043 | 0.87 | MET (0.54) | METMKNK1KEAP1PAK1DYRK1A | |
| SCHEMBL21167340 | 0.85 | MET (0.55) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL21167805 | 0.84 | MET (0.54) | METMKNK1KEAP1PAK1DYRK1A | |
| SCHEMBL21167408 | 0.83 | MKNK1 (0.53) | METMKNK1KEAP1PAK1 | |
| SCHEMBL24591117 | 0.82 | MET (0.53) | METMKNK1CSF1RNQO2KEAP1 | |
| SCHEMBL23128064 | 0.78 | MET (0.44) | METMKNK1CSF1RNQO2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-B1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | HUTCHISON MEDIPHARMA LTD (CN) | 2020-09-30 | — | — | EP | disclosed |