Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29317449 | 0.84 | ABCB1 (0.36) | ABCB1ABCC1ABCG2NPC1 | |
| SCHEMBL24591153 | 0.83 | GSK3A (0.39) | MAPK10BRAFPDE10ANPC1RAB9A | |
| SCHEMBL29314464 | 0.82 | NPC1 (0.36) | PDE10AABCB1ABCC1ABCG2NPC1 | |
| SCHEMBL21167442 | 0.82 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL29314565 | 0.82 | MET (0.34) | BRAFIGF1RMEN1KMT2APDE10A | |
| SCHEMBL22109644 | 0.81 | ABCB1 (0.36) | PIK3CABRAFIGF1RABCB1ABCC1 | |
| SCHEMBL22475873 | 0.80 | BRAF (0.36) | BRAFMEN1KMT2APDE10AABCB1 | |
| SCHEMBL24591158 | 0.80 | MET (0.35) | BRAFPDE10A | |
| SCHEMBL24591103 | 0.80 | GRM5 (0.36) | ABCB1ABCC1ABCG2NPC1 | |
| SCHEMBL21167554 | 0.79 | HDAC6 (0.34) | PDE10ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |