Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 6/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16882503 | 0.90 | BRAF (0.40) | PDE10ABRAFIGF1RMETROCK1 | |
| SCHEMBL21167653 | 0.81 | BACE1 (0.42) | PDE10ABRAFIGF1RROCK1NPC1 | |
| SCHEMBL12486158 | 0.80 | PDE10A (0.39) | PDE10ABRAFIGF1RMETROCK1 | |
| SCHEMBL21167642 | 0.79 | POLB (0.44) | NPC1RAB9ACLK1CLK2DYRK1A | |
| SCHEMBL12482778 | 0.77 | BRAF (0.39) | PDE10ABRAFIGF1RMETNPC1 | |
| SCHEMBL21167710 | 0.76 | CLK1 (0.37) | PDE10ABRAFIGF1RMETNPC1 | |
| SCHEMBL22475714 | 0.74 | BACE1 (0.41) | PDE10ABRAFIGF1RNPC1RAB9A | |
| SCHEMBL21167631 | 0.74 | BACE1 (0.44) | PDE10ABRAFIGF1RNPC1RAB9A | |
| SCHEMBL12693345 | 0.73 | MET (0.53) | MET | |
| SCHEMBL24591105 | 0.72 | HDAC3 (0.36) | METNPC1HDAC3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |