Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 3/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167711 | 0.81 | KDR (0.42) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL22475982 | 0.79 | ABCB1 (0.39) | MAPTNPC1HDAC3ALDH1A1MET | |
| SCHEMBL24591153 | 0.79 | GSK3A (0.39) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16882503 | 0.78 | BRAF (0.40) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL21167654 | 0.76 | PDE10A (0.40) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL21167331 | 0.76 | SYK (0.37) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL12486158 | 0.75 | PDE10A (0.39) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL21167377 | 0.75 | MAT2A (0.39) | DYRK1APDE10AHDAC3MET | |
| SCHEMBL22475868 | 0.75 | HDAC3 (0.37) | DYRK1APDE10ARAB9ANPC1HDAC3 | |
| SCHEMBL22475688 | 0.74 | HDAC3 (0.42) | HDAC3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-B1 | CERTAIN TRIAZOLOPYRAZINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | HUTCHISON MEDIPHARMA LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |