Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22475911 | 0.81 | MEN1 (0.47) | POLBKMT2AMEN1TDP1SLC40A1 | |
| SCHEMBL21167654 | 0.79 | PDE10A (0.40) | MAPTRAB9ANPC1CLK1CLK2 | |
| SCHEMBL21167710 | 0.74 | CLK1 (0.37) | ALDH1A1MAPTRAB9ANPC1CLK1 | |
| SCHEMBL12489339 | 0.73 | MET (0.50) | POLBKMT2AMEN1TDP1SLC40A1 | |
| SCHEMBL24591154 | 0.72 | MEN1 (0.46) | POLBKMT2AMEN1TDP1SLC40A1 | |
| SCHEMBL12487899 | 0.71 | CHRM1 (0.44) | — | |
| SCHEMBL24591105 | 0.71 | HDAC3 (0.36) | SMN1; SMN2ALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL16882503 | 0.68 | BRAF (0.40) | ALDH1A1RAB9ANPC1CLK1CLK2 | |
| SCHEMBL28050970 | 0.67 | PDE10A (0.55) | POLBALDH1A1MAPTHTTRAB9A | |
| SCHEMBL25295878 | 0.67 | RAB9A (0.51) | ALDH1A1KDM4EMAPTTSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |