Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | RAB9A | P51151 | 9/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.55 |
| ▸ | STAT1 | P42224 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510224 | 0.91 | DYRK1A (0.49) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL211547 | 0.87 | CSNK1D (0.46) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL210507 | 0.87 | CSNK1D (0.47) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL4342546 | 0.87 | RAB9A (0.58) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL211696 | 0.86 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL211950 | 0.85 | CSNK1D (0.45) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL8535100 | 0.82 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8509643 | 0.81 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL210936 | 0.81 | ALDH1A1 (0.41) | NPC1RAB9ASMN1; SMN2STAT1ALDH1A1 | |
| SCHEMBL4347836 | 0.81 | CSNK1D (0.51) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |