Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.35 |
| ▸ | CDK9 | P50750 | 3/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CCND3 | P30281 | 2/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | BCL6 | P41182 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19557698 | 0.88 | CCNA2 (0.38) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL19557729 | 0.83 | MAPK8 (0.42) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL24073506 | 0.78 | CCNA2 (0.44) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL30223473 | 0.78 | CCNA2 (0.44) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL25839416 | 0.75 | LRRK2 (0.43) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL16204249 | 0.74 | CDK9 (0.41) | ULK1CDK2CCNA2CDK9CCNK | |
| SCHEMBL24716303 | 0.74 | KMT2A (0.44) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL2062564 | 0.73 | IGF1R (0.54) | ULK1CDK2CCNA2CDK9CCNK | |
| SCHEMBL30833698 | 0.72 | ULK1 (0.43) | ULK1MAPK8CDK2CCNA2CDK9 | |
| SCHEMBL17879578 | 0.72 | CDK9 (0.39) | ULK1CDK2CCNA2CDK9CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2990405-B1 | DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS | SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN) | 2019-07-17 | — | — | EP | disclosed |