Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 5/20 | 0.38 |
| ▸ | CDK2 | P24941 | 5/20 | 0.38 |
| ▸ | CCNK | O75909 | 3/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.38 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21169786 | 0.88 | ULK1 (0.35) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL19557729 | 0.87 | MAPK8 (0.42) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL24073506 | 0.82 | CCNA2 (0.44) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL30223473 | 0.82 | CCNA2 (0.44) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL25839416 | 0.78 | LRRK2 (0.43) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL16204249 | 0.77 | CDK9 (0.41) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL24716303 | 0.77 | KMT2A (0.44) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL2062564 | 0.77 | IGF1R (0.54) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL17879578 | 0.75 | CDK9 (0.39) | CCNA2CDK2CCNKCDK9CCND3 | |
| SCHEMBL17879582 | 0.73 | CDK9 (0.38) | CCNA2CDK2CCNKCDK9CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10618884-B2 | Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds | SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-04-14 | — | — | US | disclosed |
| US-20180044323-A1 | DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS | SUZHOU ZELGEN BIOPHARMACEUTICALS CO LTD (CN) | 2018-02-15 | — | — | US | disclosed |
| US-9809572-B2 | Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds | SUZHOU ZELGEN BIOPHARMACEUTICALS CO., LTD. (CN) | 2017-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10618884-B2 | Deuterated diaminopyrimidine compounds and pharmaceutical compositions comprising such compounds | DCK, DPYD, BRAF | CCNA2 1287/4885CDK2 73/4885CCNK 213/4885 |
| US-20180044323-A1 | DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS | DCK, DPYD, BRAF | CCNA2 1287/4885CDK2 73/4885CCNK 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.