Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 4/20 | 0.39 |
| ▸ | IL1B | P01584 | 8/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287831 | 0.91 | PSEN1 (0.39) | QPCTIL1BPSEN1PSEN2APH1B | |
| SCHEMBL14990531 | 0.83 | QPCT (0.46) | QPCTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12289987 | 0.79 | JAK2 (0.44) | — | |
| SCHEMBL21170244 | 0.79 | NPBWR1 (0.38) | IL1BTNF | |
| SCHEMBL21170124 | 0.79 | ABL1 (0.37) | IL1BTNFNPC1MAPTRAB9A | |
| SCHEMBL21170341 | 0.78 | IL1B (0.39) | IL1BTNFNPC1MAPTRAB9A | |
| SCHEMBL21170312 | 0.78 | ABL1 (0.47) | — | |
| SCHEMBL21170299 | 0.77 | NPC1 (0.47) | IL1BTNFPSEN1PSEN2APH1B | |
| SCHEMBL12287847 | 0.76 | PSEN1 (0.38) | IL1BTNFPSEN1PSEN2APH1B | |
| SCHEMBL21170272 | 0.76 | IL1B (0.39) | IL1BTNFNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |