Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 6/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170038 | 0.86 | DPP4 (0.42) | HPGDSFYNCLK1LDHBPIK3CA | |
| SCHEMBL12287723 | 0.86 | DPP4 (0.42) | HPGDSFYNCLK1LDHBPIK3CA | |
| SCHEMBL12287289 | 0.86 | DPP4 (0.42) | HPGDSFYNCLK1LDHBPIK3CA | |
| SCHEMBL21170446 | 0.83 | HPGDS (0.44) | HPGDSFYNLDHBPIK3CAMAPK8 | |
| SCHEMBL21170083 | 0.82 | FYN (0.42) | HPGDSFYNLDHBPIK3CAMAPK8 | |
| SCHEMBL12287323 | 0.81 | NPC1 (0.40) | HPGDSFYNLDHBPIK3CAMAPK8 | |
| SCHEMBL12286690 | 0.81 | LDHB (0.47) | FYNLDHBPIK3CAMAPK8MAPK9 | |
| SCHEMBL19422102 | 0.79 | FYN (0.40) | FYNLDHBPIK3CAMAPK8MAPK9 | |
| SCHEMBL19422104 | 0.79 | FYN (0.40) | FYNLDHBPIK3CAMAPK8MAPK9 | |
| SCHEMBL12287611 | 0.79 | HPGDS (0.42) | HPGDSFYNCLK1PIK3CAMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |