Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 9/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287727 | 0.88 | FPR2 (0.39) | IL1BCYP3A4PORCNSCN10A | |
| SCHEMBL12287310 | 0.87 | CYP11B1 (0.39) | IL1BPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21170477 | 0.82 | IL1B (0.35) | IL1BTNF | |
| SCHEMBL21170475 | 0.81 | IL1B (0.35) | IL1BTNFNPC1RAB9AMEN1 | |
| SCHEMBL2563223 | 0.81 | NPY5R (0.38) | IL1BTNFNPC1RAB9AMEN1 | |
| SCHEMBL21170397 | 0.81 | IL1B (0.38) | IL1BTNFNPC1RAB9AMEN1 | |
| SCHEMBL12288231 | 0.81 | NPC1 (0.51) | IL1BTNFNPC1RAB9AMEN1 | |
| SCHEMBL21170361 | 0.80 | NPC1 (0.40) | IL1BNPC1RAB9AMEN1KMT2A | |
| SCHEMBL12287901 | 0.80 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12287126 | 0.79 | GPR55 (0.50) | NPC1RAB9AMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |