Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158096 | 0.77 | MEN1 (0.57) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL17324580 | 0.76 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL9101730 | 0.72 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL17321394 | 0.72 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL2668952 | 0.70 | PDE10A (0.47) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL7195074 | 0.69 | PDE10A (0.45) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL20250778 | 0.68 | MEN1 (0.47) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL9933090 | 0.65 | PDE10A (0.45) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL21389568 | 0.65 | PDE10A (0.45) | MEN1KMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL858832 | 0.65 | MAP4K4 (0.46) | MEN1KMT2AALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095025-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095025-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNJ11, KCNJ1 | MEN1 2978/4885KMT2A 1087/4885ALDH1A1 877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.