Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valine SCHEMBL10558548 | 0.80 | ALDH1A1 (0.40) | MAP4K4PAK4CSF1RRETGRK5 | |
| SCHEMBL2668952 | 0.77 | PDE10A (0.47) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL7195074 | 0.75 | PDE10A (0.45) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL12989975 | 0.75 | PDE10A (0.45) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL21389568 | 0.75 | PDE10A (0.45) | DYRK1APIK3CGPDE10ARAB9ANPC1 | |
| SCHEMBL259293 | 0.75 | PDE10A (0.45) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL9933090 | 0.75 | PDE10A (0.45) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL10921639 | 0.75 | PDE10A (0.45) | PIK3CGPDE10ARAB9ANPC1ALDH1A1 | |
| SCHEMBL5225420 | 0.72 | NPC1 (0.40) | PDE10ARAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL9101730 | 0.72 | ALDH1A1 (0.55) | RAB9ANPC1ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220378794-A1 | TREATING COGNITIVE DISORDERS USING TRAPIDIL | SINOPIA BIOSCIENCES, INC. | 2022-12-01 | — | — | US | claimed |
| EP-4069239-A1 | TREATING COGNITIVE DISORDERS USING TRAPIDIL | Sinopia Biosciences, Inc. (US) | 2022-10-12 | — | — | EP | claimed |
| US-20070129383-A1 | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-06-07 | — | — | US | claimed |
| EP-1674454-A1 | SUBSTITUTED 2-AMINO- 1,2,4 TRIAZOLO 1,5-a PYRIMIDINE DERIVATIVE AND USE THEREOF | Nippon Kayaku Kabushiki Kaisha (JP) | 2006-06-28 | — | — | EP | claimed |
| EP-0717743-B1 | N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES | DOW AGROSCIENCES LLC (US) | 2001-11-14 | — | — | EP | claimed |
| WO-1996001826-A1 | N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES | DOWELANCO (US) | 1996-01-25 | — | — | WO | claimed |
| JP-60185782-A | — | — | None | — | — | JP | disclosed |
| JP-61165364-A | — | — | None | — | — | JP | disclosed |
| US-20250387396-A1 | TREATING EXTRAPYRAMIDAL SYNDROME USING TRAPIDIL | SINOPIA BIOSCIENCES INC (US) | 2025-12-25 | — | — | US | disclosed |
| EP-3442538-B1 | TREATING LEVODOPA-INDUCED DYSKINESIA USING TRAPIDIL | SINOPIA BIOSCIENCES INC (US) | 2025-07-23 | — | — | EP | disclosed |
| EP-4217346-B1 | NEW COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2025-07-02 | — | — | EP | disclosed |
| US-12268691-B2 | Treating extrapyramidal syndrome using trapidil | SINOPIA BIOSCIENCES, INC. (US) | 2025-04-08 | — | — | US | disclosed |
| EP-4259626-B1 | PROCESS FOR THE PREPARATION 4-(3,5-DIFLUOROPHENYL)-N-[3-(6-METHYLPYRIMIDIN-4-YL)-3- AZABICYCLO[3.2.1]OCTAN-8-YL]-6,7-DIHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-2-AMINE | HOFFMANN LA ROCHE (CH) | 2025-01-29 | — | — | EP | disclosed |
| US-4638075-A | CHEMICAL INTERMEDIATES FOR TRIAZOLO (1,5A) PYRIMIDINES | THE DOW CHEMICAL COMPANY (US) | 1987-01-20 | — | — | US | disclosed |
| US-4638075-A | CHEMICAL INTERMEDIATES FOR TRIAZOLO (1,5A) PYRIMIDINES | THE DOW CHEMICAL COMPANY (US) | 1987-01-20 | — | — | US | disclosed |
| JP-S61165364-A | PREPARATION OF HERBICIDAL SULFONAMIDE DERIVED FROM SUBSTITUTED 2-AMINO-1,2,4-TRIAZOLO(1,5-A)PYRIMIDINE AND NOVEL INTERMEDIATE | DOW CHEMICAL CO | 1986-07-26 | — | — | JP | disclosed |
| EP-0188225-A1 | Process for the preparation of herbicidal sulfonamides derived from substituted 2-amino-1,2,4 triazolo (1,5-a) pyrimidines and novel intermediates provided therein | THE DOW CHEMICAL COMPANY (US) | 1986-07-23 | — | — | EP | disclosed |
| JP-S60185782-A | COMPOSITION AND PROCESS FOR CONTROLLING NOVEL SULFONAMIDE DERIVED FROM SUBSTITUTED 2-AMINO-1,2,4-TRIAZOLO(1,5-A) PYRIMIDINE AND UNDESIRABLE PLANT | DOW CHEMICAL CO | 1985-09-21 | — | — | JP | disclosed |
| EP-0150974-A3 | NOVEL SULFONAMIDES DERIVED FROM SUBSTITUTED 2-AMINO-1,2,4-TRIAZOLO(1,5-A)PYRIMIDINES AND COMPOSITIONS AND METHODS OF CONTROLLING UNDESIRED VEGETATION | THE DOW CHEMICAL COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |
| EP-0150974-A2 | Novel sulfonamides derived from substituted 2-amino-1,2,4-triazolo(1,5-a)pyrimidines and compositions and methods of controlling undesired vegetation | THE DOW CHEMICAL COMPANY (US) | 1985-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250387396-A1 | TREATING EXTRAPYRAMIDAL SYNDROME USING TRAPIDIL | MAP2K3, JUND, BCL2L13 | MAP4K4 69/4885PAK4 1388/4885CSF1R 1289/4885 |
| US-20220378794-A1 | TREATING COGNITIVE DISORDERS USING TRAPIDIL | SLC6A3, DRD3, DRD2 | MAP4K4 1047/4885PAK4 1284/4885CSF1R 4020/4885 |
| US-20070129383-A1 | Substituted 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivative and use thereof | ADORA1, ADORA2B, ADORA3 | MAP4K4 1958/4885PAK4 2391/4885CSF1R 3912/4885 |
| US-12268691-B2 | Treating extrapyramidal syndrome using trapidil | SLC6A3, PARK7, TAC3 | MAP4K4 1262/4885PAK4 896/4885CSF1R 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.