Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.64 |
| ▸ | CCR5 | P51681 | 1/20 | 0.64 |
| ▸ | CCR8 | P51685 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456103 | 0.87 | CCR1 (0.84) | CCR1CCR5CCR8HDAC6METAP2 | |
| Abametapir SCHEMBL29374261 | 0.80 | CCR1 (1.00) | CCR1CCR5CCR8HDAC6METAP2 | |
| Abametapir SCHEMBL351152 | 0.80 | CCR1 (1.00) | CCR1CCR5CCR8HDAC6METAP2 | |
| SCHEMBL17051503 | 0.79 | CCR1 (0.70) | CCR1CCR5CCR8HDAC6METAP2 | |
| SCHEMBL1456362 | 0.78 | ALDH1A1 (0.46) | MAOBLMNAALDH1A1GAARAB9A | |
| SCHEMBL82409 | 0.75 | — | — | |
| SCHEMBL31032336 | 0.75 | — | — | |
| SCHEMBL14804379 | 0.75 | CCR1 (0.89) | CCR1CCR5CCR8HDAC6METAP2 | |
| SCHEMBL1642418 | 0.74 | CCR1 (0.56) | CCR1CCR5CCR8HDAC6METAP2 | |
| Hydrochloric Acid SCHEMBL1254704 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3127541-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2019-07-17 | — | — | EP | disclosed |