Abametapir

Abametapir

SCHEMBL351152

Cc1ccc(-c2ccc(C)cn2)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 3/20 1.00
CCR5 P51681 3/20 1.00
CCR8 P51685 3/20 1.00
HDAC6 Q9UBN7 1/20 1.00
METAP2 P50579 1/20 0.64
CYP3A4 P08684 1/20 0.56
CYP2A6 P11509 1/20 0.56
NOS3 P29474 1/20 0.55
NOS2 P35228 1/20 0.55
GRM5 P41594 2/20 0.44
ADRA2A P08913 2/20 0.43
ADRA2B P18089 2/20 0.43
ADRA2C P18825 2/20 0.43
PLAU P00749 1/20 0.43
MAPT P10636 1/20 0.43
RAB9A P51151 1/20 0.43
ACHE P22303 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
PTGS2 P35354 2/20 0.40
ADORA2A P29274 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Abametapir SCHEMBL29374261 1.00 CCR1 (1.00) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL14804379 0.94 CCR1 (0.89) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL1456103 0.92 CCR1 (0.84) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL14804380 0.87 CCR1 (0.76) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL17051514 0.86 CCR1 (0.75) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL17051502 0.85 CCR1 (0.73) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL14804374 0.85 CCR1 (0.73) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL28454095 0.85 CCR1 (0.73) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL8025640 0.85 CCR1 (0.73) CCR1CCR5CCR8HDAC6METAP2
SCHEMBL16656145 0.85 CCR1 (0.73) CCR1CCR5CCR8HDAC6METAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 897 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727953-A2 ACCELERATED MARKING OF 5-FORMYL CYTOSINE AND USE IN NUCLEIC ACID METHYLATION SEQUENCING F. Hoffmann-La Roche AG (CH) 2026-04-22 EP claimed
US-20250375511-A1 METHOD FOR TREATING CONDITIONS ASSOCIATED WITH HYPERPROLIFERATING CELLS COMPRISING COMBINED ADMINISTRATION OF INFECTIOUS AGENTS AND METAL CATIONS THERALASE TECH INC (CA) 2025-12-11 US claimed
US-20250375458-A1 COMPOSITIONS AND METHODS TO COMBAT MULTIDRUG-RESISTANT AND PERSISTENT T-CELL-MEDIATED, ONCOLOGICAL AND INFECTIOUS DISEASES THERALASE TECH INC (CA) 2025-12-11 US claimed
US-20250114456-A1 ENHANCED IMMUNOTHERAPEUTIC METHOD COMPRISING COMBINED ADMINISTRATION OF PHOTODYNAMIC / RADIOTHERAPEUTIC COMPOUNDS AND IMMUNOTHERAPEUTIC AGENTS THERALASE TECHNOLOGIES, INC. (CA) 2025-04-10 US claimed
CN-119587710-A Application of charge crosslinked carrier as tumor chemotherapeutic medicine 中山大学 2025-03-11 CN claimed
WO-2024256358-A2 ACCELERATED MARKING OF 5-FORMYL CYTOSINE AND USE IN NUCLEIC ACID METHYLATION SEQUENCING F. HOFFMANN-LA ROCHE AG (CH) 2024-12-19 WO claimed
US-20240390364-A1 Novel Pyridine Compositions and their use in methods for preventing or treating diseases, disorders and conditions REID CHRISTOPHER BRIAN (US) 2024-11-28 US claimed
US-20240327324-A1 METHOD FOR PRODUCING FATTY ALDEHYDES AND DERIVATIVES THEREOF FMC Agricultural Solutions A/S (DK) 2024-10-03 US claimed
US-20240269066-A1 USE OF CYP450 INHIBITOR IN INHIBITING OR KILLING MITES AND TREATING XEROPHTHALMIA PRECVISION BIOTECHNOLOGIES LTD. (CN) 2024-08-15 US claimed
CN-114569612-B Application of bipyridine in preventing and treating silkworm maggot disease 江苏科技大学 2024-02-27 CN claimed
EP-0728791-B1 Process for the preparation of copolymers based on carbon monoxide and at least one compound having an alkenylic unsaturation ENICHEM SPA (IT) 1999-06-23 EP claimed
EP-0894783-A1 Process for the synthesis of phenol from benzene Enichem S.p.A. (IT) 1999-02-03 EP claimed
US-5783164-A PALLADIUM CATALYST WITH A NITROGENATED LIGAND STABLE TO OXIDATION ENICHEM S.P.A. (IT) 1998-07-21 US claimed
US-5739264-A Process for the preparation of copolymers based on carbon monoxide and at least one compound having an alkenylic unsaturation ENICHEM S.P.A. (IT) 1998-04-14 US claimed
US-5734010-A Process for the preparation of copolymers of carbon monoxide and at least one compound containing an alkenyl unsaturation ENICHEM S.P.A. (IT) 1998-03-31 US claimed
US-5717060-A Process for the preparation of copolymers based on carbon monoxide and at least one compound containing an alkenyl unsaturation ENICHEM S.P.A. (IT) 1998-02-10 US claimed
EP-0808796-A1 Process for the preparation of hydrogen peroxide ENICHEM S.p.A. (IT) 1997-11-26 EP claimed
EP-0802213-A2 Process for the preparation of copolymers of carbon monoxide and at least one compound containing an alkenyl unsaturation ENICHEM S.p.A. (IT) 1997-10-22 EP claimed
EP-0774479-A2 Process for the preparation of copolymers based on carbon monoxide and at least one compound containing an alkenyl unsaturation ENICHEM S.p.A. (IT) 1997-05-21 EP claimed
EP-0728791-A1 Process for the preparation of copolymers based on carbon monoxide and at least one compound having an alkenylic unsaturation ENICHEM S.p.A. (IT) 1996-08-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250375458-A1 COMPOSITIONS AND METHODS TO COMBAT MULTIDRUG-RESISTANT AND PERSISTENT T-CELL-MEDIATED, ONCOLOGICAL AND INFECTIOUS DISEASES CD4, TPMT, SLC11A2 CCR1 70/4885CCR5 119/4885CCR8 193/4885
US-20250114456-A1 ENHANCED IMMUNOTHERAPEUTIC METHOD COMPRISING COMBINED ADMINISTRATION OF PHOTODYNAMIC / RADIOTHERAPEUTIC COMPOUNDS AND IMMUNOTHERAPEUTIC AGENTS PDCD1, CD47, CD274 CCR1 471/4885CCR5 2069/4885CCR8 903/4885
US-20250375511-A1 METHOD FOR TREATING CONDITIONS ASSOCIATED WITH HYPERPROLIFERATING CELLS COMPRISING COMBINED ADMINISTRATION OF INFECTIOUS AGENTS AND METAL CATIONS NFATC1, PCNA, PHPT1 CCR1 2081/4885CCR5 3447/4885CCR8 3297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.