Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.38 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170815 | 0.78 | TRPA1 (0.41) | PRMT5MAP4K4LRRK2MAPT | |
| SCHEMBL17283021 | 0.77 | EGLN1 (0.41) | PRMT5MAP4K4LMNAKDM4EMAPT | |
| SCHEMBL21170731 | 0.77 | EGLN1 (0.41) | TTBK1TTBK2PRMT5KDRMAP4K4 | |
| SCHEMBL17274903 | 0.76 | JAK3 (0.45) | JAK3 | |
| SCHEMBL18776542 | 0.76 | JAK3 (0.37) | JAK3 | |
| SCHEMBL17274908 | 0.76 | JAK3 (0.45) | JAK3 | |
| SCHEMBL17283044 | 0.75 | MAP4K4 (0.41) | HTR1APRMT5KDRCLK4MAP4K4 | |
| SCHEMBL21170747 | 0.75 | PRMT5 (0.37) | PRMT5MAP4K4 | |
| SCHEMBL21170814 | 0.74 | EGLN1 (0.44) | PRMT5KDRMAP4K4LMNACYP2D6 | |
| SCHEMBL17283053 | 0.74 | EGFR (0.38) | PRMT5MAP4K4NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |