Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170737 | 0.90 | KMT2A (0.37) | PRMT5BRD4MAP4K4TRPA1EGLN1 | |
| SCHEMBL21170815 | 0.89 | TRPA1 (0.41) | PRMT5BRD4MAP4K4SNCATRPA1 | |
| SCHEMBL17283021 | 0.88 | EGLN1 (0.41) | PRMT5BRD4MAP4K4SNCATRPA1 | |
| SCHEMBL21170816 | 0.82 | TRPA1 (0.38) | PRMT5BRD4MAP4K4SNCATRPA1 | |
| SCHEMBL21170731 | 0.79 | EGLN1 (0.41) | PRMT5MAP4K4EGLN1 | |
| SCHEMBL17283053 | 0.78 | EGFR (0.38) | PRMT5MAP4K4EGLN1 | |
| SCHEMBL21170814 | 0.78 | EGLN1 (0.44) | PRMT5MAP4K4EGLN1 | |
| SCHEMBL17283044 | 0.77 | MAP4K4 (0.41) | PRMT5MAP4K4 | |
| SCHEMBL17283011 | 0.76 | MAP4K4 (0.37) | MAP4K4 | |
| SCHEMBL21170685 | 0.75 | TTBK1 (0.38) | PRMT5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |