Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.33 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.33 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17283021 | 0.86 | EGLN1 (0.41) | EGLN1PRMT5MAP4K4EGFRERBB2 | |
| SCHEMBL17283044 | 0.84 | MAP4K4 (0.41) | PRMT5MAP4K4EGFRRAB9ANPC1 | |
| SCHEMBL21170814 | 0.83 | EGLN1 (0.44) | EGLN1PRMT5MAP4K4EGFRERBB2 | |
| SCHEMBL17283053 | 0.83 | EGFR (0.38) | EGLN1PRMT5MAP4K4EGFRERBB2 | |
| SCHEMBL21170815 | 0.82 | TRPA1 (0.41) | EGLN1PRMT5MAP4K4MAPTKMT2A | |
| SCHEMBL21170816 | 0.80 | TRPA1 (0.38) | EGLN1PRMT5MAP4K4 | |
| SCHEMBL21170747 | 0.79 | PRMT5 (0.37) | EGLN1PRMT5MAP4K4 | |
| SCHEMBL21170737 | 0.77 | KMT2A (0.37) | EGLN1PRMT5MAP4K4EGFRERBB2 | |
| SCHEMBL21170685 | 0.77 | TTBK1 (0.38) | PRMT5MAP4K4MAPTTTBK1TTBK2 | |
| SCHEMBL21170732 | 0.72 | PRMT5 (0.46) | PRMT5MAP4K4EGFRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |