Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 4/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170732 | 0.77 | PRMT5 (0.46) | ADKMAP4K4RETABL1EGFR | |
| SCHEMBL21170661 | 0.76 | SNCA (0.37) | ADKMAP4K4RETLRRK2CHEK1 | |
| SCHEMBL21170681 | 0.71 | SNCA (0.39) | MAP4K4RETLRRK2CHEK1PRMT5 | |
| SCHEMBL31326450 | 0.68 | PRMT5 (0.34) | RETLRRK2PRMT5PI4KAPI4K2B | |
| SCHEMBL17283039 | 0.67 | CYP2A6 (0.41) | AURKAABL1KDRCDK9DYRK1A | |
| SCHEMBL17283021 | 0.66 | EGLN1 (0.41) | MAP4K4EGFRPRMT5GRM5SNCA | |
| SCHEMBL21170731 | 0.66 | EGLN1 (0.41) | MAP4K4KDREGFRPRMT5MAPT | |
| SCHEMBL21170747 | 0.66 | PRMT5 (0.37) | MAP4K4PRMT5SNCA | |
| SCHEMBL17283041 | 0.66 | RET (0.39) | RETLRRK2LCKPRMT5PI4KA | |
| SCHEMBL2491796 | 0.66 | GRM5 (0.55) | ADKGRM5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |