Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | ADK | P55263 | 2/20 | 0.42 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PI4KA | P42356 | 2/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170681 | 0.81 | SNCA (0.39) | PRMT5SNCARETMAP4K4PI4KA | |
| SCHEMBL21170661 | 0.80 | SNCA (0.37) | PRMT5ADKSNCAABL1RET | |
| SCHEMBL17274798 | 0.78 | AHR (0.53) | PRMT5RETMAPTEGFR | |
| SCHEMBL21170735 | 0.77 | ADK (0.46) | PRMT5ADKSNCAABL1RET | |
| SCHEMBL17283039 | 0.76 | CYP2A6 (0.41) | PRMT5SNCAABL1ADORA2API4KB | |
| SCHEMBL17283041 | 0.75 | RET (0.39) | PRMT5SNCARETPI4KAPI4K2B | |
| SCHEMBL21170669 | 0.73 | GRM5 (0.47) | SNCAGRM5MAPTGRM4APP | |
| SCHEMBL17283021 | 0.72 | EGLN1 (0.41) | PRMT5SNCAMAP4K4GRM5MAPT | |
| SCHEMBL21170731 | 0.72 | EGLN1 (0.41) | PRMT5MAP4K4MAPTEGFR | |
| SCHEMBL17274658 | 0.72 | PRMT5 (0.49) | PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |