Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170747 | 0.90 | PRMT5 (0.37) | TRPA1BRD4MAP4K4PRMT5EGLN1 | |
| SCHEMBL21170815 | 0.89 | TRPA1 (0.41) | KMT2ATRPA1BRD4MAP4K4SMN1; SMN2 | |
| SCHEMBL17283021 | 0.86 | EGLN1 (0.41) | TRPA1BRD4MAP4K4EGFRSMN1; SMN2 | |
| SCHEMBL21170816 | 0.81 | TRPA1 (0.38) | TRPA1BRD4MAP4K4PRMT5EGLN1 | |
| SCHEMBL21170731 | 0.77 | EGLN1 (0.41) | KMT2AMAP4K4EGFRSMN1; SMN2ERBB2 | |
| SCHEMBL17283053 | 0.77 | EGFR (0.38) | MAP4K4EGFRERBB2ERBB4PRMT5 | |
| SCHEMBL21170814 | 0.77 | EGLN1 (0.44) | MAP4K4EGFRMAPK1ERBB2ERBB4 | |
| SCHEMBL17283044 | 0.75 | MAP4K4 (0.41) | MAP4K4EGFRMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17274689 | 0.75 | EGFR (0.48) | EGFRERBB2PIK3CDPIK3CA | |
| SCHEMBL18776549 | 0.75 | EGFR (0.40) | EGFRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145512-B1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | JIANGSU HENGRUI MEDICINE CO (CN) | 2019-07-17 | — | — | EP | disclosed |