Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.63 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.55 |
| ▸ | FAAH | O00519 | 4/20 | 0.49 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 3/20 | 0.41 |
| ▸ | CES1 | P23141 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117121 | 1.00 | PLA2G2A (0.63) | PLA2G2APLA2G5FAAHPLA2G4ANOD1 | |
| SCHEMBL2773210 | 0.83 | PLA2G2A (0.58) | PLA2G2APLA2G5PLA2G4ANOD1PLA2G2C | |
| SCHEMBL2773637 | 0.83 | PLA2G2A (0.58) | PLA2G2APLA2G5PLA2G4ANOD1PLA2G2C | |
| SCHEMBL2773206 | 0.83 | PLA2G2A (0.58) | PLA2G2APLA2G5PLA2G4ANOD1PLA2G2C | |
| SCHEMBL2771857 | 0.82 | PLA2G2A (0.62) | PLA2G2APLA2G5PLA2G4ASIRT6SIRT1 | |
| SCHEMBL2771859 | 0.82 | PLA2G2A (0.62) | PLA2G2APLA2G5PLA2G4ASIRT6SIRT1 | |
| SCHEMBL2770510 | 0.82 | PLA2G2A (0.72) | PLA2G2APLA2G5PLA2G4ANOD1PLA2G2C | |
| SCHEMBL2120784 | 0.81 | PLA2G2A (0.69) | PLA2G2APLA2G5FAAHPLA2G4AMEN1 | |
| SCHEMBL2120792 | 0.81 | PLA2G2A (0.69) | PLA2G2APLA2G5FAAHPLA2G4AMEN1 | |
| SCHEMBL2769449 | 0.79 | PLA2G2A (0.72) | PLA2G2APLA2G5FAAHPLA2G4ANOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580852-B2 | 2-oxamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudopeptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120095096-A1 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-04-19 | — | — | US | disclosed |
| WO-2010123832-A2 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095096-A1 | 2-OXAMIDE INHIBITORS OF PHOSPHOLIPASE A2 ACTIVITY AND CELLULAR ARACHIDONATE RELEASE BASED ON DIPEPTIDES AND PSEUDOPEPTIDES | PLA2G2E, PLA2G4A, PLAA | PLA2G2A 6/4885PLA2G5 16/4885FAAH 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.