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Sugi Predict / Targets / PLAA

PLAA

Phospholipase A-2-activating protein · Q9Y263 · PLAA on Sugi Atlas →

2,988 patent compounds predicted against PLAA, 2,208 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL8568782 SCHEMBL8568782 0.54 10/20
Bromide Bromide (SCHEMBL10528511) 0.49 10/20
Bromide Bromide (SCHEMBL6010245) 0.55 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL3846897) 0.47 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL3846894) 0.42 8/20
Bromide Bromide (SCHEMBL6010235) 0.55 6/20
SCHEMBL105705 SCHEMBL105705 0.55 6/20
SCHEMBL2991009 SCHEMBL2991009 0.53 6/20
SCHEMBL6403309 SCHEMBL6403309 0.51 6/20
Adrenalone Adrenalone (SCHEMBL123124) 0.49 6/20
SCHEMBL1703207 SCHEMBL1703207 0.53 5/20
SCHEMBL9356659 SCHEMBL9356659 0.53 5/20
SCHEMBL2989544 SCHEMBL2989544 0.51 5/20
SCHEMBL10352002 SCHEMBL10352002 0.50 5/20
SCHEMBL421462 SCHEMBL421462 0.49 5/20
SCHEMBL9336299 SCHEMBL9336299 0.45 5/20
SCHEMBL10042364 SCHEMBL10042364 0.38 5/20
SCHEMBL9053836 SCHEMBL9053836 0.53 4/20
SCHEMBL9768134 SCHEMBL9768134 0.48 4/20
SCHEMBL9768082 SCHEMBL9768082 0.47 4/20

Clinical trials — most relevant to PLAA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL) PHASE4COMPLETED
Comparative Assessment of Preoperative Versus Postoperative Submucosal Dexamethasone on Postoperative Complications Following Surgical Extraction of Mandibular Third Molar: Randomized Controlled Trial PHASE4NOT_YET_RECRUITING
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis PHASE3COMPLETED
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM PHASE3COMPLETED
European Celecoxib Trial in Primary Breast Cancer PHASE3COMPLETED
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes PHASE3UNKNOWN
Lovaza's Effect on the Activation of Platelets PHASE2COMPLETED
Assessment of Coronary Plaque Composition PHASE1COMPLETED
SB-659032 Platelet Aggregation Study PHASE1COMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies nanUNKNOWN
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis. nanCOMPLETED
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes nanCOMPLETED
Oxidative Stress, Anxiety and Depression in Breast Cancer Patients: Impact of Music Therapy nanCOMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke nanCOMPLETED
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant nanCOMPLETED
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis nanUNKNOWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects nanUNKNOWN
Positron Emission Tomography (PET) to Study Brain Signaling nanCOMPLETED
Mucomyst for Hepatitis C nanSUSPENDED
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors nanUNKNOWN
Lp-PLA2 and Coronary Atherosclerosis in Humans nanCOMPLETED
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients nanCOMPLETED
Psychological and Biological Markers of Refractory Migraine nanUNKNOWN
High Dose Omega-3 Fatty Acids in the Treatment of Sport Related Concussions nanCOMPLETED
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery nanENROLLING_BY_INVITATION
Role of Anti-mouse PLA2R1 ELISA in Membranous Nephropathy nanCOMPLETED
Role of PLA2G1B During HIV Infection nanUNKNOWN
Molecular Markers of Human Sperm Function nanWITHDRAWN
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PLAA binder may also engage these)

ProteinNameSimilarity
P27612 — 1.000 P27612 →
P54319 — 0.998 P54319 →
Q6GM65 — 0.998 Q6GM65 →
Q08DS7 — 0.977 Q08DS7 →
F4IDS7 — 0.976 F4IDS7 →
O00423 — 0.976 O00423 →
Q6DDM4 — 0.975 Q6DDM4 →
Q5RAC9 — 0.974 Q5RAC9 →
Q9BXC9 — 0.974 Q9BXC9 →
Q9BPX3 — 0.974 Q9BPX3 →
ANAPC7 Anaphase-promoting complex subunit 7 0.973 landscape →
O22785 — 0.973 O22785 →
Q5IH13 — 0.973 Q5IH13 →
Q676U5 — 0.973 Q676U5 →
Q9AV81 — 0.973 Q9AV81 →
A1A4I9 — 0.972 A1A4I9 →
Q8N1G2 — 0.972 Q8N1G2 →
GTF3C3 General transcription factor 3C polypeptide 3 0.972 landscape →
Q3UR70 — 0.972 Q3UR70 →
Q8CCJ3 — 0.971 Q8CCJ3 →
E9Q912 — 0.971 E9Q912 →
A7MBJ5 — 0.971 A7MBJ5 →
Q9P2H3 — 0.971 Q9P2H3 →
Q8VZM1 — 0.971 Q8VZM1 →
Q99MH9 — 0.970 Q99MH9 →
Q8WUH2 — 0.970 Q8WUH2 →
IPO7 Importin-7 0.970 landscape →
O89079 — 0.970 O89079 →
Q5U5D4 — 0.970 Q5U5D4 →
Q6IQS6 — 0.970 Q6IQS6 →