Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | HBB | P68871 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29950717 | 0.77 | PIK3CG (0.53) | CYP2C19PIK3CGPIK3C3ALDH1A1KDM4E | |
| SCHEMBL2115743 | 0.77 | ALDH1A1 (0.52) | CYP2C19PIK3CGPIK3C3ALDH1A1KDM4E | |
| SCHEMBL8840800 | 0.69 | CYP2C19 (0.51) | CYP2C19ALDH1A1KDM4ETP53HBB | |
| SCHEMBL2117280 | 0.69 | ALDH1A1 (0.39) | PIK3CGPIK3C3ALDH1A1KDM4ETP53 | |
| SCHEMBL2118527 | 0.69 | PDPK1 (0.44) | CYP2C19ALDH1A1TP53HBBSMN1; SMN2 | |
| Mercaptopurine Anhydrous SCHEMBL3895 | 0.68 | ALDH1A1 (0.54) | ALDH1A1KDM4ETP53HBBSMN1; SMN2 | |
| SCHEMBL13593784 | 0.67 | PIK3CG (0.50) | CYP2C19PIK3CGPIK3C3ALDH1A1TDP1 | |
| Mercaptopurine Anhydrous SCHEMBL141410 | 0.66 | ALDH1A1 (0.52) | ALDH1A1KDM4ETP53HBBSMN1; SMN2 | |
| SCHEMBL7990063 | 0.65 | ALDH1A1 (0.47) | PIK3CGPIK3C3ALDH1A1KDM4ENPC1 | |
| SCHEMBL2414856 | 0.65 | ALDH1A1 (0.47) | PIK3CGPIK3C3ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119351-A1 | THERAPY OF TUMORS AND INFECTIOUS AGENTS DEFICIENT IN METHYLTHIOADENOSINE PHOSPHORYLASE | LUBIN ADAM (US) | 2015-04-30 | — | — | US | disclosed |
| US-8796241-B2 | Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase | LUBIN ADAM (US) | 2014-08-05 | — | — | US | disclosed |
| US-20120094947-A1 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | LUBIN ADAM (US) | 2012-04-19 | — | — | US | disclosed |
| EP-2192905-A2 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | Lubin, Adam (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009032057-A2 | METHOD FOR THE SELECTIVE THERAPY OF DISEASE | LUBIN ADAM (US) | 2009-03-12 | — | — | WO | disclosed |
| US-5652359-A | Oligonucleotides containing n-methyl thiolated bases having antiviral activity | EPOCH PHARMACEUTICALS, INC. (US) | 1997-07-29 | — | — | US | disclosed |