SCHEMBL2118527

SCHEMBL2118527

Cn1c(N)nc2nc[nH]c2c1=S

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.44
GDA Q9Y2T3 1/20 0.44
HRH4 Q9H3N8 1/20 0.43
MAP3K5 Q99683 1/20 0.42
CDK2 P24941 6/20 0.42
DPP4 P27487 1/20 0.42
PNP P00491 1/20 0.41
CDK1 P06493 5/20 0.40
CCNB1 P14635 5/20 0.40
CCNA2 P20248 5/20 0.40
CCNA1 P78396 5/20 0.40
XDH P47989 2/20 0.38
PI4KA P42356 2/20 0.38
PI4K2B Q8TCG2 2/20 0.38
PI4K2A Q9BTU6 2/20 0.38
PI4KB Q9UBF8 2/20 0.38
LMNA P02545 2/20 0.38
DRD3 P35462 1/20 0.38
LRRK2 Q5S007 1/20 0.38
PIN1 Q13526 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20867 0.79 ATAD2 (0.53) PDPK1GDAHRH4DPP4PNP
Water SCHEMBL27738785 0.78 ADORA2A (0.54) PDPK1GDAHRH4DPP4PNP
Hydrochloric Acid SCHEMBL27339406 0.78 ATAD2 (0.51) PDPK1GDAHRH4DPP4PNP
SCHEMBL27602647 0.76 ATAD2 (0.49) PDPK1GDAHRH4DPP4PNP
SCHEMBL28385765 0.73 DPP4 (0.41) PDPK1GDAHRH4MAP3K5CDK2
SCHEMBL27752224 0.73 CYP2C19 (0.43) PDPK1GDAHRH4MAP3K5CDK2
SCHEMBL2118529 0.72 ALDH1A1 (0.36) XDHLMNAADORA3USP2ALDH1A1
Acetic Acid SCHEMBL1404482 0.72 MGMT (0.43) GDACDK2DPP4PNPCDK1
Thiophene SCHEMBL27638390 0.71 ATAD2 (0.44) PDPK1GDAHRH4DPP4PNP
SCHEMBL9705493 0.70 CDK2 (0.39) PDPK1GDACDK2DPP4PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 319 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106695-A1 TARGETED NANOPARTICLES ENCAPSULATING WATER-SOLUBLE THERAPEUTICS, METHODS OF PRODUCTION, AND USE OPTIMEOS LIFE SCIENCES, INC. (US) 2026-05-21 WO disclosed
WO-2026103877-A1 LIPID COMPOUND AND LIPID NANOPARTICLE COMPOSITION 中生复诺健生物科技(上海)有限公司 2026-05-21 WO disclosed
WO-2026098357-A1 FREEZE-DRIED NUCLEIC ACID-LOADED LIPID NANOPARTICLE AND RECONSTITUTION METHOD THEREOF KUDO BIOTECHNOLOGY, INC. (US) 2026-05-15 WO disclosed
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS PFIZER INC. (US) 2026-05-14 US disclosed
WO-2026088119-A1 LIPIDATED TLR7/8 MODULATORS AS ADJUVANTS AND USES THEREOF PFIZER INC. (US) 2026-04-30 WO disclosed
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION TRILINK BIOTECHNOLOGIES, LLC (US) 2026-04-23 US disclosed
EP-4728076-A1 METHOD FOR STABILIZING RNA Pfizer Inc. (US) 2026-04-22 EP disclosed
EP-4720094-A1 MUTATED FRAGMENT OF VZV GLYCOPROTEIN E Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-08 EP disclosed
US-12594242-B2 Lipid compounds and lipid nanoparticle compositions Suzhou Abogen Biosciences Co., Ltd. (CN) 2026-04-07 US disclosed
US-20260078082-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS MODERNATX INC (US) 2026-03-19 US disclosed
US-20090029399-A1 METHOD FOR RAPID DETERMINATION OF THIOPURINE METHYLTRANSFERASE ACTIVITY MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH, A MINNESOTA CORPORATION 2009-01-29 US disclosed
US-7452689-B2 Method for rapid determination of thiopurine methyltransferase activity MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2008-11-18 US disclosed
US-20060263840-A1 Method for rapid determination of thiopurine methyltransferase activity MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , A MINNESOTA CORPORATION 2006-11-23 US disclosed
US-20040047845-A1 Methods and compositions for diagnosis and treatment of cancer based on the transcription factor ets2 MUSC FOUNDATION FOR RESEARCH DEVELOPMENT 2004-03-11 US disclosed
EP-1133575-A4 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER BASED ON THE TRANSCRIPTION FACTOR ETS2 MUSC FOUND FOR RES DEV (US) 2003-08-13 EP disclosed
US-20020081601-A1 Methods and compositions for diagnosis and treatment of cancer based on the transcription factor ets2 MUSC FOUNDATION FOR RESEARCH DEVELOPMENT. 2002-06-27 US disclosed
EP-1133575-A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER BASED ON THE TRANSCRIPTION FACTOR ETS2 MUSC Foundation For Research Development (US) 2001-09-19 EP disclosed
WO-2000042214-A1 PHOSPHATE RELEASE ENZYME ASSAY PANTHERIX LTD. (GB) 2000-07-20 WO disclosed
WO-2000030590-A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER BASED ON THE TRANSCRIPTION FACTOR ETS2 MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) 2000-06-02 WO disclosed
US-5652359-A Oligonucleotides containing n-methyl thiolated bases having antiviral activity EPOCH PHARMACEUTICALS, INC. (US) 1997-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260109977-A1 MODIFIED RNA FOR INCREASING PROTEIN EXPRESSION RNGTT, RNMT, UPF1 PDPK1 4714/4885GDA 1345/4885HRH4 4870/4885
US-20260130987-A1 VACCINATION AGAINST PNEUMOCCOCAL AND COVID-19 INFECTIONS SARS1, CD14, PYCARD PDPK1 1692/4885GDA 4245/4885HRH4 4318/4885
US-12594242-B2 Lipid compounds and lipid nanoparticle compositions NPC1, NPC1L1, PLIN3 PDPK1 2259/4885GDA 3402/4885HRH4 1861/4885
US-20260078082-A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS PHOSPHO1, LIPC, SDCBP PDPK1 799/4885GDA 3996/4885HRH4 2788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.