Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21173226 | 0.94 | MAPT (0.39) | USP8USP7USP47MAPTALDH1A1 | |
| SCHEMBL21173227 | 0.84 | MAPT (0.36) | MAPTALDH1A1PKMGAAEGFR | |
| SCHEMBL25656474 | 0.84 | MAPT (0.36) | MAPTALDH1A1PKMGAAEGFR | |
| SCHEMBL21173222 | 0.83 | CASP3 (0.39) | MAPTALDH1A1PKMGAAEGFR | |
| SCHEMBL21173223 | 0.83 | S100A4 (0.43) | USP8USP7USP47MAPTALDH1A1 | |
| SCHEMBL2681526 | 0.80 | S100A4 (0.42) | USP8USP7MAPTALDH1A1PKM | |
| SCHEMBL16977316 | 0.80 | S100A4 (0.42) | USP8USP7MAPTALDH1A1PKM | |
| SCHEMBL2681524 | 0.80 | S100A4 (0.42) | USP8USP7MAPTALDH1A1PKM | |
| SCHEMBL24960484 | 0.79 | MAPT (0.36) | MAPTALDH1A1PKMGAAEGFR | |
| SCHEMBL22544872 | 0.79 | S100A4 (0.41) | USP8USP7MAPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019137354-A1 | THIOPHENE-BASED FUSED AROMATIC SYSTEMS | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-07-18 | — | — | WO | disclosed |