SCHEMBL21173223

SCHEMBL21173223

C/C=C1\C(=O)c2cc(Cl)ccc2C1=C(C#N)C#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.43
USP8 P40818 2/20 0.40
USP7 Q93009 2/20 0.40
USP47 Q96K76 1/20 0.40
HSP90AA1 P07900 1/20 0.39
MAPT P10636 2/20 0.36
PKM P14618 2/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
GABRA1 P14867 4/20 0.34
GABRG2 P18507 4/20 0.34
GABRB3 P28472 4/20 0.34
EGFR P00533 2/20 0.33
PPOX P50336 1/20 0.33
IDO1 P14902 1/20 0.33
TDO2 P48775 1/20 0.33
TGM2 P21980 1/20 0.33
METAP1 P53582 1/20 0.33
KDM4E B2RXH2 1/20 0.32
GABRB1 P18505 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21173228 0.94 USP8 (0.40) S100A4USP8USP7USP47HSP90AA1
SCHEMBL21173224 0.84 LCK (0.36) MAPTPKMALDH1A1GAAEGFR
SCHEMBL25656471 0.84 LCK (0.36) MAPTPKMALDH1A1GAAEGFR
SCHEMBL21173222 0.83 CASP3 (0.39) MAPTPKMALDH1A1GAAEGFR
SCHEMBL21173221 0.83 USP8 (0.40) USP8USP7USP47MAPTPKM
SCHEMBL2681526 0.80 S100A4 (0.42) S100A4USP8USP7HSP90AA1MAPT
SCHEMBL2681524 0.80 S100A4 (0.42) S100A4USP8USP7HSP90AA1MAPT
SCHEMBL16977316 0.80 S100A4 (0.42) S100A4USP8USP7HSP90AA1MAPT
SCHEMBL25747895 0.80 ALDH1A1 (0.33) MAPTPKMALDH1A1GAAEGFR
SCHEMBL24960484 0.79 MAPT (0.36) MAPTPKMALDH1A1GAAEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019137354-A1 THIOPHENE-BASED FUSED AROMATIC SYSTEMS THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2019-07-18 WO disclosed