Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 19/20 | 0.54 |
| ▸ | PPARA | Q07869 | 9/20 | 0.54 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810419 | 0.95 | PPARD (0.52) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4809886 | 0.93 | PPARD (0.53) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4809868 | 0.93 | PPARD (0.56) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4808025 | 0.93 | PPARD (0.65) | PPARDPPARAPPARGMEN1ALDH1A1 | |
| SCHEMBL4803322 | 0.92 | PPARD (0.54) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4808683 | 0.91 | PPARD (0.51) | PPARDPPARAPPARGFFAR1 | |
| SCHEMBL4802632 | 0.91 | PPARD (0.53) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4862555 | 0.90 | PPARD (0.52) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4811165 | 0.89 | PPARD (0.56) | PPARDPPARAPPARGFFAR1MEN1 | |
| SCHEMBL4804962 | 0.89 | PPARD (0.51) | PPARDPPARAPPARGFFAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229998-B2 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-12 | — | — | US | claimed |
| US-20070072871-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | BANKER PIERETTE | 2007-03-29 | — | — | US | claimed |
| US-20060052603-A1 | Process for preparing substituted phenoxy-acetic acids from phenols | SMITHLKINE BEECHAM CORPORATION | 2006-03-09 | — | — | US | claimed |
| EP-1546124-A1 | PROCESS FOR PREPARING SUBSTITUTED PHENOXY-ACETIC ACIDS FROM PHENOLS | SmithKline Beecham Corporation (US) | 2005-06-29 | — | — | EP | claimed |
| EP-1349843-B1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | SMITHKLINE BEECHAM CORP (US) | 2005-04-20 | — | — | EP | claimed |
| US-20040077659-A1 | Method for treating ppar gamma mediated diseases or conditions | SMITHKLINE BEECHAM CORPORATION | 2004-04-22 | — | — | US | claimed |
| US-20040072838-A1 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors | SMITHKLINE BEECHAM CORPORATION | 2004-04-15 | — | — | US | claimed |
| WO-2004026849-A1 | PROCESS FOR PREPARING SUBSTITUTED PHENOXY-ACETIC ACIDS FROM PHENOLS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-01 | — | — | WO | claimed |
| EP-1368011-A1 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | claimed |
| EP-1349843-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2003-10-08 | — | — | EP | claimed |
| WO-2002067912-A2 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES OR CONDITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | claimed |
| WO-2002059098-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2002-08-01 | — | — | WO | claimed |
| CN-105512415-B | A kind of batch approximating method of non-linear dose-effect curve | 青岛农业大学 | 2018-07-10 | — | — | CN | disclosed |
| US-20120094959-A1 | TREATMENT OF CYSTIC DISEASES | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION | 2012-04-19 | — | — | US | disclosed |
| US-20110224264-A1 | MEDICAMENTS | BROWN KATHLEEN KEATING | 2011-09-15 | — | — | US | disclosed |
| US-20110224264-A1 | MEDICAMENTS | BROWN KATHLEEN KEATING | 2011-09-15 | — | — | US | disclosed |
| EP-1368011-A1 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES | SmithKline Beecham Corporation (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1349843-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002067912-A2 | METHOD FOR TREATING PPAR GAMMA MEDIATED DISEASES OR CONDITIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-06 | — | — | WO | disclosed |
| WO-2002059098-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | GLAXO GROUP LIMITED (GB) | 2002-08-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224264-A1 | MEDICAMENTS | GLS, PKD1, ATP6V1B1 | PPARD 7/4885PPARA 4/4885PPARG 6/4885 |
| US-20070072871-A1 | THIAZOLE AND OXAZOLE DERIVATIVES AS ACTIVATORS OF HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | PPARD, PPARG, PPARA | PPARD 1/4885PPARA 3/4885PPARG 2/4885 |
| US-20040077659-A1 | Method for treating ppar gamma mediated diseases or conditions | PPARG, PPARA, PPARD | PPARD 3/4885PPARA 2/4885PPARG 1/4885 |
| US-20060052603-A1 | Process for preparing substituted phenoxy-acetic acids from phenols | HPD, PAH, GNPAT | PPARD 695/4885PPARA 194/4885PPARG 100/4885 |
| US-20120094959-A1 | TREATMENT OF CYSTIC DISEASES | CFTR, LPCAT3, LPCAT1 | PPARD 21/4885PPARA 27/4885PPARG 35/4885 |
| US-20040072838-A1 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors | PPARA, PPARG, PPARD | PPARD 3/4885PPARA 1/4885PPARG 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.