SCHEMBL2117455

SCHEMBL2117455

ClCc1nc(Cl)c(Cl)c(Cl)n1

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10779914 0.82
SCHEMBL81512 0.75 NPC1 (0.32) KMT2A
SCHEMBL2117963 0.73
SCHEMBL10907064 0.71 ALDH1A1 (0.53)
SCHEMBL2116123 0.69
SCHEMBL2115243 0.67 HRH3 (0.32)
SCHEMBL2117543 0.67
SCHEMBL2118363 0.67 CYP1A2 (0.36) KMT2A
SCHEMBL2117199 0.67 KDM4E (0.32)
SCHEMBL218726 0.65 ALDH1A1 (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101646657-B Process for producing trichloropyrimidine compound SUMITOMO CHEMICAL CO JP 2012-08-08 CN disclosed
US-8158787-B2 Process for producing trichloropyrimidine compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-04-17 US disclosed
US-20100160630-A1 PROCESS FOR PRODUCING TRICHLOROPYRIMIDINE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-24 US disclosed
EP-2128141-A1 PROCESS FOR PRODUCING TRICHLOROPYRIMIDINE COMPOUND Sumitomo Chemical Company, Limited (JP) 2009-12-02 EP disclosed
EP-1296957-A2 SYNTHESIS OF CHLORINATED PYRIMIDINES Syngenta Limited (GB) 2003-04-02 EP disclosed
US-20020042514-A1 Synthesis of chlorinated pyrimidines SYNGENTA LIMITED (GB) 2002-04-11 US disclosed
WO-2002000628-A2 SYNTHESIS OF CHLORINATED PYRIMIDINES SYNGENTA LIMITED (GB) 2002-01-03 WO disclosed
US-6160117-A Chemical process ZENECA LIMITED (GB) 2000-12-12 US disclosed
EP-0125650-B1 REACTIVE DYES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE DYEING AND PRINTING OF SUBSTRATES BAYER AG (DE) 1987-04-01 EP disclosed
EP-0125650-A2 Reactive dyes, process for their preparation and their use in the dyeing and printing of substrates BAYER AG (DE) 1984-11-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020042514-A1 Synthesis of chlorinated pyrimidines DPYD, TYMP, TYMS KMT2A 1160/4885
US-20100160630-A1 PROCESS FOR PRODUCING TRICHLOROPYRIMIDINE COMPOUND DPYD, TYMP, TST KMT2A 3104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.