SCHEMBL21176556

SCHEMBL21176556

COC(=O)c1ccc(C(F)(F)F)cc1N([SH](=O)=O)C(F)(F)F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFTR P13569 2/20 0.57
KDM4E B2RXH2 5/20 0.43
MAPT P10636 4/20 0.43
ALDH1A1 P00352 3/20 0.40
HPGD P15428 3/20 0.40
HSD17B10 Q99714 2/20 0.40
USP2 O75604 1/20 0.40
CYP2C19 P33261 1/20 0.40
CES2 O00748 2/20 0.40
MRGPRX4 Q96LA9 2/20 0.39
NOTUM Q6P988 1/20 0.38
GAA P10253 1/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
PDK2 Q15119 1/20 0.36
PDK4 Q16654 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28906830 0.81 CFTR (0.55) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL7550401 0.78 CFTR (0.57) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL29243244 0.77 CFTR (0.50) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL22263091 0.77 CFTR (0.73) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL7554661 0.77 KMT2A (0.59) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL167426 0.76 CFTR (0.71) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL28510653 0.74 CFTR (0.47) CFTRKDM4EMAPTMRGPRX4
SCHEMBL422201 0.74 CFTR (0.69) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL28172968 0.74 CFTR (0.69) CFTRKDM4EMAPTALDH1A1HPGD
SCHEMBL694388 0.74 CFTR (0.69) CFTRKDM4EALDH1A1HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10793520-B2 Sulfonylaminobenzamide compound and pest control agent NIPPON SODA CO., LTD. (JP) 2020-10-06 US disclosed
US-20190225577-A1 SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2019-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225577-A1 SULFONYLAMINOBENZAMIDE COMPOUND AND PEST CONTROL AGENT CBR3, CBR1, HRH2 CFTR 634/4885KDM4E 1440/4885MAPT 4792/4885
US-10793520-B2 Sulfonylaminobenzamide compound and pest control agent CBR3, CBR1, HRH2 CFTR 634/4885KDM4E 1440/4885MAPT 4792/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.