Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Methoxyisatin SCHEMBL29506298 | 0.82 | ALDH1A1 (1.00) | ALDH1A1PDE3BPDE3ALRRK2MAPT | |
| 5-Methoxyisatin SCHEMBL21602 | 0.82 | ALDH1A1 (1.00) | ALDH1A1PDE3BPDE3ALRRK2MAPT | |
| 5-Methoxyisatin SCHEMBL3935863 | 0.81 | ALDH1A1 (0.96) | ALDH1A1PDE3BPDE3ALRRK2MAPT | |
| SCHEMBL14446594 | 0.79 | CES1 (0.72) | ALDH1A1LRRK2MAPTRETTGM2 | |
| SCHEMBL5918370 | 0.78 | ALDH1A1 (0.68) | ALDH1A1KDM4EPDE3BPDE3ALRRK2 | |
| SCHEMBL20246772 | 0.77 | ALDH1A1 (0.66) | ALDH1A1PDE3BPDE3ALRRK2MAPT | |
| SCHEMBL19928099 | 0.77 | ALDH1A1 (0.66) | ALDH1A1PDE3BPDE3ALRRK2MAPT | |
| SCHEMBL31107477 | 0.77 | ROS1 (0.61) | ALDH1A1KDM4ELRRK2MAPTSMN1; SMN2 | |
| SCHEMBL10061666 | 0.77 | ROS1 (0.61) | ALDH1A1KDM4ELRRK2MAPTSMN1; SMN2 | |
| SCHEMBL18505834 | 0.76 | LRRK2 (0.61) | ALDH1A1KDM4EGLAHPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47731-E1 | Kinase inhibitors and method of treating cancer with same | UNIV HEALTH NETWORK (CA) | 2019-11-19 | — | — | US | disclosed |
| US-10358436-B2 | Kinase inhibitors and method of treating cancer | UNIVERSITY HEALTH NETWORK (CA) | 2019-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358436-B2 | Kinase inhibitors and method of treating cancer | MAP3K6, MAP3K5, MAP3K19 | ALDH1A1 2389/4885KDM4E 883/4885GLA 2924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.