Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.76 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.76 |
| ▸ | DRD3 | P35462 | 4/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.76 |
| ▸ | DRD1 | P21728 | 3/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.76 |
| ▸ | DRD2 | P14416 | 2/20 | 0.76 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL3682874 | 1.00 | CYP2D6 (0.76) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL7343108 | 0.89 | CHRM2 (0.64) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL7343102 | 0.89 | CHRM2 (0.64) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL599319 | 0.88 | CYP2D6 (0.78) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL10367408 | 0.88 | CYP2D6 (0.62) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL10367407 | 0.88 | CYP2D6 (0.62) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Isothipendyl SCHEMBL19555662 | 0.88 | KMT2A (0.81) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL26777 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL29372077 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539216-B2 | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same | INNERCAP TECHNOLOGIES, INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160136100-A1 | MULTI-PHASE, MULTI-COMPARTMENT, CAPSULAR DELIVERY APPARATUS AND METHODS FOR USING SAME | INNERCAP TECHNOLOGIES, INC. | 2016-05-19 | — | — | US | disclosed |
| US-9241911-B2 | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using same | INNERCAP TECHNOLOGIES, INC. | 2016-01-26 | — | — | US | disclosed |
| US-20140212482-A1 | MULTI-PHASE, MULTI-COMPARTMENT, CAPSULAR DELIVERY APPARATUS AND METHODS FOR USING SAME | INNERCAP TECHNOLOGIES, INC. | 2014-07-31 | — | — | US | disclosed |
| US-20130136791-A1 | MULTI-PHASE, MULT-COMPARTMENT CAPSULAR DELIVERY APPARATUS AND METHODS FOR USING SAME | MILLER FRED H (US) | 2013-05-30 | — | — | US | disclosed |
| US-8361497-B2 | Multi-phase, multi-compartment, capsular delivery apparatus and methods for using the same | INNERCAP TECHNOLOGIES, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120093923-A1 | Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses, Or Conditions | INNERCAP TECHNOLOGIES, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20100233254-A1 | MULTI-PHASE, MULTI-COMPARTMENT, CAPSULAR DELIVERY APPARATUS AND METHODS FOR USING THE SAME | INNERCAP TECHNOLOGIES, INC. (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100221321-A1 | Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions | INNERCAP TECHNOLOGIES, INC. (US) | 2010-09-02 | — | — | US | disclosed |
| US-20050008690-A1 | Supplying active materials in various phases in single dosage multicompartment capsule | INNERCAP TECHNOLOGIES, INC. | 2005-01-13 | — | — | US | disclosed |