Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.78 |
| ▸ | HTR1A | P08908 | 4/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.78 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.78 |
| ▸ | DRD3 | P35462 | 4/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.78 |
| ▸ | LMNA | P02545 | 3/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.78 |
| ▸ | DRD1 | P21728 | 3/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.78 |
| ▸ | DRD2 | P14416 | 2/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL26777 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL4700 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL29372077 | 0.89 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL2118132 | 0.88 | CYP2D6 (0.76) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL3682874 | 0.88 | CYP2D6 (0.76) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL2962420 | 0.87 | LMNA (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL5501515 | 0.87 | LMNA (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL41904 | 0.87 | LMNA (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL5425141 | 0.87 | LMNA (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160128944-A1 | COATED PARTICLES AND COMPOSITIONS COMPRISING SAME | VYOME THERAPEUTICS LIMITED (IN) | 2016-05-12 | — | — | US | claimed |
| EP-3003031-A1 | COATED PARTICLES AND COMPOSITIONS COMPRISING SAME | Vyome Biosciences Pvt Ltd (IN) | 2016-04-13 | — | — | EP | claimed |
| WO-2014195872-A1 | COATED PARTICLES AND COMPOSITIONS COMPRISING SAME | VYOME BIOSCIENCES PVT. LTD. (IN) | 2014-12-11 | — | — | WO | claimed |
| US-20140248270-A1 | METHOD FOR TOPICAL TREATMENT OF TAR-RESPONSIVE DERMATOLOGICAL DISORDERS | YU RUEY J (US) | 2014-09-04 | — | — | US | claimed |
| EP-2723452-A2 | CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS | Vyome Biosciences Pvt Ltd (IN) | 2014-04-30 | — | — | EP | claimed |
| WO-2012177986-A2 | CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS | VYOME BIOSCIENCES (IN) | 2012-12-27 | — | — | WO | claimed |
| US-20120040920-A1 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | YU RUEY J (US) | 2012-02-16 | — | — | US | claimed |
| US-20110091403-A1 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | YU RUEY J | 2011-04-21 | — | — | US | claimed |
| US-20100247463-A1 | N-(PHOSPHONOALKYL)-AMINO ACIDS, DERIVATIVES THEREOF AND COMPOSITIONS AND METHODS OF USE | YU RUEY J | 2010-09-30 | — | — | US | claimed |
| US-7776844-B2 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use | YU RUEY J | 2010-08-17 | — | — | US | claimed |
| US-20040033963-A1 | Urea composition | YU RUEY J (US) | 2004-02-19 | — | — | US | claimed |
| WO-2004010968-A1 | NON-AMPHOTERIC GLUTATHIONE DERIVATIVE COMPOSITIONS FOR TOPICAL APPLICATION | YU RUEY J (US) | 2004-02-05 | — | — | WO | claimed |
| US-20030229141-A1 | N-acetyl cysteine and its topical use | YU RUEY J (US) | 2003-12-11 | — | — | US | claimed |
| WO-2003086291-A2 | UREA COMPOSITIONS | YU RUEY J (US) | 2003-10-23 | — | — | WO | claimed |
| US-20030108496-A1 | Compositions comprising phenyl-glycine derivatives | YU RUEY J (US) | 2003-06-12 | — | — | US | claimed |
| WO-2003045338-A1 | COMPOSITIONS COMPRISING PHENYL-GLYCINE DERIVATIVES | YU RUEY J (US) | 2003-06-05 | — | — | WO | claimed |
| EP-1227820-A2 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | Yu, Ruey J., Dr. (US) | 2002-08-07 | — | — | EP | claimed |
| US-20020028227-A1 | Oligosaccharide aldonic acids and their topical use | YU RUEY J (US) | 2002-03-07 | — | — | US | claimed |
| US-6335023-B1 | VEHICLES AND OLIGOSACCHARIDE ALDONIC ACIDS | YU RUEY J (US) | 2002-01-01 | — | — | US | claimed |
| WO-2001001932-A2 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | YU RUEY J (US) | 2001-01-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110091403-A1 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | GLA, ALDOA, FUT6 | HRH1 2049/4885CYP2D6 3399/4885CHRM2 1634/4885 |
| US-20030108496-A1 | Compositions comprising phenyl-glycine derivatives | GRHPR, ARL1, SUCLG1 | HRH1 49/4885CYP2D6 1865/4885CHRM2 4274/4885 |
| US-20020028227-A1 | Oligosaccharide aldonic acids and their topical use | GLA, ALDOA, MAN2A1 | HRH1 2041/4885CYP2D6 2918/4885CHRM2 1319/4885 |
| US-20120040920-A1 | OLIGOSACCHARIDE ALDONIC ACIDS AND THEIR TOPICAL USE | GLA, ALDOA, FUT6 | HRH1 2049/4885CYP2D6 3399/4885CHRM2 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.