Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 6/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.64 |
| ▸ | DRD3 | P35462 | 6/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.64 |
| ▸ | HRH1 | P35367 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR2C | P28335 | 2/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.63 |
| ▸ | DRD1 | P21728 | 5/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343108 | 1.00 | CHRM2 (0.64) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| SCHEMBL10367408 | 0.95 | CYP2D6 (0.62) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| SCHEMBL10367407 | 0.95 | CYP2D6 (0.62) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| Hydrochloric Acid SCHEMBL10368127 | 0.94 | LMNA (0.62) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| Hydrochloric Acid SCHEMBL10368129 | 0.94 | LMNA (0.62) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| Promethazine SCHEMBL2118132 | 0.89 | CYP2D6 (0.76) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| Promethazine SCHEMBL3682874 | 0.89 | CYP2D6 (0.76) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| SCHEMBL7343026 | 0.84 | CYP2D6 (0.72) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| Propiomazine SCHEMBL3863991 | 0.83 | CHRM2 (0.88) | CHRM2HTR1ACHRM1ADRA1AOPRM1 | |
| SCHEMBL10369438 | 0.83 | CHRM2 (0.58) | CHRM2HTR1ACHRM1ADRA1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117302-B1 | PHENOTHIAZINE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-06-27 | — | — | EP | claimed |
| EP-0117302-B1 | PHENOTHIAZINE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-06-27 | — | — | EP | disclosed |
| US-4833138-A | Phenothiazinealkaneamines for treatment of neurotoxic injury | WASHINGTON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |
| EP-0117302-A2 | Phenothiazine derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-09-05 | — | — | EP | disclosed |