Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.76 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.76 |
| ▸ | DRD3 | P35462 | 4/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.76 |
| ▸ | DRD1 | P21728 | 3/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.76 |
| ▸ | DRD2 | P14416 | 2/20 | 0.76 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL2118132 | 1.00 | CYP2D6 (0.76) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL7343108 | 0.89 | CHRM2 (0.64) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL7343102 | 0.89 | CHRM2 (0.64) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL599319 | 0.88 | CYP2D6 (0.78) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL10367408 | 0.88 | CYP2D6 (0.62) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| SCHEMBL10367407 | 0.88 | CYP2D6 (0.62) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Isothipendyl SCHEMBL19555662 | 0.88 | KMT2A (0.81) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL26777 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A | |
| Promethazine SCHEMBL29372077 | 0.87 | CYP2D6 (1.00) | CYP2D6CHRM2HTR1ACHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099650-A1 | NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH | KNAUER KENT A | 2010-04-22 | — | — | US | claimed |
| WO-2008070264-A2 | NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH | CASE WESTERN RESERVE UNIVERSITY (US) | 2008-06-12 | — | — | WO | claimed |
| US-5948414-A | DECONGESTANT, ANTIHISTAMINE, NATURAL OIL OR EXTRACT, NONIONIC EMULSIFIER, TRITERPENE SAPONIN ADJUVANT, WATER | NOUVEAU TECHNOLOGIES, INC. (US) | 1999-09-07 | — | — | US | claimed |
| CN-117242080-A | Boron-containing pyrazole compounds, compositions comprising the same, methods and uses thereof | 勃林格殷格翰动物保健美国公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-112154145-B | Piperazine azaspiro derivatives | 辉瑞大药厂 | 2023-10-17 | — | — | CN | disclosed |
| CN-114303061-A | Modulating extracellular matrix movement | 尤瓦尔·林克维奇 | 2022-04-08 | — | — | CN | disclosed |
| CN-107849017-B | 1,1, 1-trifluoro-3-hydroxypropan-2-ylcarbamate derivatives and 1,1, 1-trifluoro-4-hydroxybutyl-2-ylcarbamate derivatives as MAGL inhibitors | 辉瑞公司 | 2021-03-30 | — | — | CN | disclosed |
| CN-111051304-A | Novel imidazo [4,5-c ] quinoline derivatives as LRRK2 inhibitors | 辉瑞大药厂 | 2020-04-21 | — | — | CN | disclosed |
| US-20160220583-A1 | AQUEOUS NASAL SPRAY COMPOSITION OF CORTICOSTEROIDS AND ANTIHISTAMINIC AGENTS | GAVIS PHARMACEUTICALS (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160220584-A1 | AQUEOUS NASAL SPRAY COMPOSITION OF CORTICOSTEROIDS | GAVIS PHARMACEUTICALS (US) | 2016-08-04 | — | — | US | disclosed |
| US-20100099650-A1 | NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH | KNAUER KENT A | 2010-04-22 | — | — | US | disclosed |
| WO-2008070264-A2 | NASAL SPRAY COMPOSITION AND METHOD FOR TREATING RHINITIS, SINUSITIS OR BOTH | CASE WESTERN RESERVE UNIVERSITY (US) | 2008-06-12 | — | — | WO | disclosed |
| US-5948414-A | DECONGESTANT, ANTIHISTAMINE, NATURAL OIL OR EXTRACT, NONIONIC EMULSIFIER, TRITERPENE SAPONIN ADJUVANT, WATER | NOUVEAU TECHNOLOGIES, INC. (US) | 1999-09-07 | — | — | US | disclosed |