SCHEMBL21185019

SCHEMBL21185019

CCc1c(F)ccc2c1CSc1ccccc1C2

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
ALOX12 P18054 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21185009 0.81 HDAC9 (0.31) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL19939944 0.80 RYR2 (0.32) ALDH1A1HPGDTDP1
SCHEMBL20015049 0.78 RYR2 (0.30)
SCHEMBL20015243 0.77 DRD2 (0.34) ALDH1A1HPGDTDP1TP53
SCHEMBL24831713 0.75 MEN1 (0.33) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL21185263 0.72 ALDH1A1 (0.35) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL20014517 0.70 MEN1 (0.43) ALDH1A1MAPTHPGDALOX12TDP1
SCHEMBL20123665 0.70 RYR2 (0.34) ALDH1A1HPGDTDP1
SCHEMBL22813506 0.69
SCHEMBL19940394 0.69 ALDH1A1 (0.32) ALDH1A1MAPTHPGDALOX12TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019141179-A1 PYRIDONE DERIVATIVE, COMPOSITION THEREOF AND APPLICATION THEREOF AS ANTI-INFLUENZA DRUG 银杏树药业(苏州)有限公司 2019-07-25 WO disclosed