Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.31 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19939944 | 0.84 | RYR2 (0.32) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL21185009 | 0.81 | HDAC9 (0.31) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL20014517 | 0.80 | MEN1 (0.43) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL20015243 | 0.77 | DRD2 (0.34) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL20015049 | 0.75 | RYR2 (0.30) | RYR2 | |
| SCHEMBL21185019 | 0.75 | ALDH1A1 (0.31) | ALDH1A1HPGDMAPTALOX12TDP1 | |
| SCHEMBL20123827 | 0.71 | HSD17B3 (0.30) | MEN1KMT2AHSD17B3 | |
| SCHEMBL20014743 | 0.70 | HSD17B3 (0.40) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL20014752 | 0.70 | TRPA1 (0.37) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL20123457 | 0.70 | DRD2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3290424-B1 | SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES AND PRODRUG THEREOF | SHIONOGI & CO (JP) | 2023-01-04 | — | — | EP | disclosed |