Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 2/20 | 0.43 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | CCR9 | P51686 | 5/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116901 | 0.86 | TRIM24 (0.49) | CYP3A4POLBGHSRRAB9AMAPT | |
| SCHEMBL2118198 | 0.85 | GHSR (0.42) | POLBGHSRRAB9AMAPTLMNA | |
| SCHEMBL2119877 | 0.80 | EDNRA (0.40) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2121588 | 0.79 | CYP3A4 (0.46) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2119257 | 0.79 | POLB (0.48) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2118685 | 0.79 | POLB (0.57) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2120014 | 0.79 | POLB (0.51) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2121436 | 0.79 | POLB (0.51) | CYP3A4CYP2D6PSEN1PSEN2APH1B | |
| SCHEMBL2121415 | 0.79 | ACLY (0.54) | MTORPIK3CG | |
| SCHEMBL2121407 | 0.79 | GHSR (0.42) | POLBKMT2AGHSRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | ELARA PHARMACEUTICALS GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| EP-2382190-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS | European Molecular Biology Laboratory (EMBL) (DE) | 2011-11-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095012-A1 | TOLUIDINE SULFONAMIDES AND THEIR USE | HIF1A, HIF1AN, EGLN3 | CYP3A4 1975/4885CYP2D6 2336/4885PSEN1 1682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.