SCHEMBL21186

SCHEMBL21186

CC(=O)n1ccc(N)nc1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.43
LMNA P02545 3/20 0.37
THRB P10828 1/20 0.37
MTOR P42345 1/20 0.37
MDM2 Q00987 1/20 0.37
NCOA1 Q15788 1/20 0.37
NCOA3 Q9Y6Q9 1/20 0.37
PDE3A Q14432 3/20 0.35
CACNA1F O60840 2/20 0.35
ALB P02768 2/20 0.35
MAPT P10636 2/20 0.35
CACNA1D Q01668 2/20 0.35
CACNA1S Q13698 2/20 0.35
CACNA1C Q13936 2/20 0.35
GABRP O00591 2/20 0.35
GABRD O14764 2/20 0.35
GABRA1 P14867 2/20 0.35
GABRB1 P18505 2/20 0.35
GABRG2 P18507 2/20 0.35
GABRB3 P28472 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL27916787 0.98 NOTUM (0.42) NOTUMLMNATHRBMTORMDM2
SCHEMBL27740855 0.96 NOTUM (0.41) NOTUMLMNATHRBMTORMDM2
Cytosine SCHEMBL6839378 0.86 NOTUM (0.34) NOTUMLMNATHRBMTORMDM2
SCHEMBL20801121 0.83 FGFR1 (0.37) NOTUMLMNATHRBMTORMDM2
SCHEMBL10679054 0.82 LMNA (0.38) LMNATHRBMTORMDM2NCOA1
SCHEMBL27819780 0.82 PARP1 (0.43) LMNATHRBMTORMDM2NCOA1
SCHEMBL22540523 0.81 LMNA (0.35) NOTUMLMNATHRBMTORMDM2
SCHEMBL25858533 0.81 PDE3A (0.36) NOTUMLMNATHRBMTORMDM2
SCHEMBL3240144 0.80 ELANE (0.37) LMNATHRBMTORMDM2NCOA1
SCHEMBL1334906 0.80 CYP11B1 (0.38) LMNATHRBMTORMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2510 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4684016-A2 METHODS AND MATERIALS FOR TREATING CANCER The Regents of the University of California (US) 2026-01-28 EP claimed
WO-2024197047-A2 METHODS AND MATERIALS FOR TREATING CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-09-26 WO claimed
US-20230287032-A1 SYNTHESIS OF FLUORINATED NUCLEOTIDES MERCK SHARP & DOHME LLC (US) 2023-09-14 US claimed
US-11731959-B2 Troxacitabine synthesis and crystal form thereof BEIJING HEBABIZ BIOTECHNOLOGY CO., INC. (CN) 2023-08-22 US claimed
EP-4196131-A1 SYNTHESIS OF FLUORINATED NUCLEOTIDES Merck Sharp & Dohme LLC (US) 2023-06-21 EP claimed
US-20230148152-A1 METHOD OF SYNTHESIZING SINGLE-STRANDED NUCLEOTIDE SEQUENCE, BLOCKED NUCLEOSIDE TRIPHOSPHATES AND RELATED METHODS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2023-05-11 US claimed
CN-115433263-A Defensin derived from human oral actinomycetes, and coding gene and application thereof 中国科学院动物研究所 2022-12-06 CN claimed
CN-115322100-A Delta, epsilon-alkenyl ketone compound and preparation method and application thereof 南京工业大学 2022-11-11 CN claimed
CN-109425670-B Method for detecting fatigue degree of team based on human urine 中国民用航空局民用航空医学中心 2022-09-16 CN claimed
CN-109425669-B Method for screening biomarkers related to fatigue degree in human body fluid by liquid chromatography-mass spectrometry 中国民用航空局民用航空医学中心 2022-09-16 CN claimed
CN-1566112-A Diastereoselective preparation method of lamivudine TRI LION PHARMACEUTICAL CO LTD (CN) 2005-01-19 CN claimed
WO-2004013182-A1 HYALURONIC ACID DERIVATIVES JASPER LTD LIABILITY CO. (US) 2004-02-12 WO claimed
US-20030089472-A1 For oxidation of lignin-containing materials (wood pulp) CODEXIS, INC. 2003-05-15 US claimed
WO-2003023134-A1 LACCASE ACTIVITY ENHANCERS FOR PULP BLEACHING CODEXIS INC (US) 2003-03-20 WO claimed
EP-0763047-B1 NOVEL METHOD OF PRODUCING NUCLEOSIDES HOECHST AG (DE) 2002-01-23 EP claimed
US-5780607-A PYRANOSYL NUCLEOSIDE MONOMER UNITS CONNECTED BY AMIDE LINKAGES HOFFMANN-LA ROCHE INC. (US) 1998-07-14 US claimed
WO-1997014709-A1 ANTISENSE OLIGOMERS F. HOFFMANN-LA ROCHE AG (CH) 1997-04-24 WO claimed
CN-1128269-A Oligoribonucleotides with amide backbone HOFFMANN LA ROCHE (CH) 1996-08-07 CN claimed
EP-0714907-A1 Oligoribonucleotides with amide backbone F. HOFFMANN-LA ROCHE AG (CH) 1996-06-05 EP claimed
WO-1994015622-A1 NUCLEOSIDE DERIVATIVES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS CAMBRIDGE NEUROSCIENCE (US) 1994-07-21 WO claimed